Antidepressants on trial: how valid is the evidence?
نویسنده
چکیده
A recent meta-analysis concluded that newer antidepressant drugs are equivalent to or no better than placebos, a conclusion at some variance with their commonly judged clinical effectiveness. The 'disconnect' between randomised controlled trials and clinical practice would benefit from dissection of contributing factors, and redressing limitations to current trial procedures.
منابع مشابه
Management of depression after stroke: a systematic review of pharmacological therapies.
BACKGROUND AND PURPOSE Although depression may affect recovery and outcome after stroke, it is often overlooked or inadequately managed, and there is uncertainty regarding the benefits of antidepressant therapy in this setting. We aimed to assess the effectiveness of antidepressants for the treatment and prevention of depression after stroke. METHODS We undertook a systematic review using Coc...
متن کاملSuicidality with selective serotonin reuptake inhibitors: Valid claim?
The red flags raised by the 1990 clinical reports of increased suicidality associated with treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine were followed by anecdotal reports of similar symptoms with other antidepressants of the same class. Recent discussions by Healy have argued in favour of a suicidogenic potential of the SSRIs. This paper reviews the relevant liter...
متن کاملClinical inquiries: How should you manage a depressed patient unresponsive to an SSRI?
The best approach among studied alternatives to manage a patient with treatment-resistant depression is not clear from the evidence. All of the options reviewed seem to have about a 25% to 30% success rate. Switching to other antidepressants or augmenting with non-antidepressant drugs has the best supporting evidence (strength of recommendation [SOR]: B).1 Adding additional antidepressants (SOR...
متن کاملThe value of randomized clinical trials in ophthalmology.
T HE RANDOMIZED CLINICAL TRIAL IS THE GOLD standard for evaluating a therapy, providing the highest evidence for the practice of evidence-based medicine. However, not all randomized clinical trials are informative and the success of the trial in demonstrating a valid treatment or diagnostic effect will depend on the elements of the study design. The purpose of this report is to highlight the es...
متن کاملThe Efficacy of Physiotherapy Interventions for Recovery of Patients Suffering from Piriformis Syndrome: A Literature Review
Background and Objectives: Piriformis syndrome is a neuromuscular disease mostly caused by compression of the sciatic nerve by the piriformis muscle. The purpose of this study was to review the efficacy of different types of physiotherapy interventions on the signs and symptoms in patients with piriformis syndrome. Materials and Methods: PubMed, Scopus, Web of Science and Google Scholar databa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The British journal of psychiatry : the journal of mental science
دوره 194 1 شماره
صفحات -
تاریخ انتشار 2009